Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Chloramine-T-Mediated Oxidation of Benzylic Alcohols Using Indium(III) Triflate
Kazuhide NakaharaChie KitazawaTomoko Mineno
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2017 Volume 65 Issue 8 Pages 801-804

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Abstract

The efficient oxidation of benzylic alcohols to carbonyl compounds was performed using chloramine-T and a catalytic amount of indium(III) triflate. The primary benzylic alcohols were converted to the corresponding aldehydes in a good yield, and the secondary benzylic alcohols were oxidized to ketones in a high yield. The optimized reaction conditions required 0.3 eq of indium(III) triflate and the use of acetonitrile as a solvent.

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© 2017 The Pharmaceutical Society of Japan
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