Anthraquinone and Butenolide Constituents from the Crinoid Capillaster multiradiatus

Le Thi Vien; Tran Thi Hong Hanh; Phan Thi Thanh Huong; Nguyen Hai Dang; Nguyen Van Thanh; Nguyen Xuan Cuong; Nguyen Hoai Nam; Do Cong Thung; Phan Van Kiem; Chau Van Minh

doi:10.1248/cpb.c18-00472

Regular Articles

Anthraquinone and Butenolide Constituents from the Crinoid Capillaster multiradiatus

Le Thi Vien, Tran Thi Hong Hanh, Phan Thi Thanh Huong, Nguyen Hai Dang, Nguyen Van Thanh, Nguyen Xuan Cuong , Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh

Author information

Keywords: Capillaster multiradiatus, crinoid, anthraquinone, nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2)

JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary material

2018 Volume 66 Issue 11 Pages 1023-1026

DOI https://doi.org/10.1248/cpb.c18-00472

Browse “Advance online publication” version

Details

Abstract

Seven anthraquinones including two new compounds namely capillasterquinones A and B (1 and 2) and one new butenolide namely capillasterolide (8) were isolated and structurally elucidated from the crinoid Capillaster multiradiatus. The inhibitory effect of compounds 1–8 on lipopolysaccharide (LPS)-induced nitric oxide (NO) production as well as inhibition of 1 on expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) proteins in RAW264.7 cells were also evaluated. As the obtained results, capillasterquinone A (1) showed strong NO production inhibitory activity with an IC₅₀ of 5.89±0.11 µM. In addition, compound 1 reduced the LPS-induced iNOS and COX-2 expressions in a dose-dependent manner.

Graphical Abstract Fullsize Image

Corresponding author

Register with J-STAGE for free!