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Facile Total Synthesis of (+)-Spinoxazine B
2018 Volume 66 Issue 12 Pages 1196-1198
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2018 Volume 66 Issue 12 Pages 1196-1198
Herein we describe a short total synthesis of (+)-spinoxazine B, which inhibits nitric oxide (NO) production in BV-2 microgrial cells. Spinoxazine B is the first example of a natural alkaloid containing an oxazinone-pyrrolidone nucleus, and it is expected to serve as a novel drug lead compound as well as a drug discovery scaffold.
