Sydowianumols A, B, and C, Three New Compounds from Discomycete Poculum pseudosydowianum

Daiki Kawashima; Tsuyoshi Hosoya; Hiroshi Tomoda; Masaki Kita; Hideyuki Shigemori

doi:10.1248/cpb.c18-00264

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Sydowianumols A, B, and C, Three New Compounds from Discomycete Poculum pseudosydowianum

Daiki Kawashima, Tsuyoshi Hosoya, Hiroshi Tomoda, Masaki Kita, Hideyuki Shigemori

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Keywords: Poculum pseudosydowianum, endophytic fungus, Quercus crispula, sydowianumol, antimicrobial activity, methicillin-resistant Staphylococcus aureus (MRSA)

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Supplementary material

2018 Volume 66 Issue 8 Pages 826-829

DOI https://doi.org/10.1248/cpb.c18-00264

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Abstract

Three new compounds, sydowianumols A (1), B (2), and C (3), were isolated from culture broth and mycelial extracts of Poculum pseudosydowianum (TNS-F-57853), an endophytic fungus isolated from fresh leaves of Quercus crispula. The structures of new compounds 1–3 were elucidated from spectroscopic data. Sydowianumols A (1) and B (2) exhibited antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) with 90% minimum inhibitory concentration (MIC₉₀) values of 12.5 µg/mL.

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