Notes
First Total Synthesis of the Pavine Alkaloid (±)-Neocaryachine and Its Optical Resolution
2020 年 68 巻 9 号 p. 899-902
詳細
2020 年 68 巻 9 号 p. 899-902
The first total synthesis of (±)-neocaryachine (1) was achieved using a radical cyclization to produce the dibenzo-9-azabicyclo[3.3.1]nonane pavine skeleton, following a Bischler–Napieralski reaction to construct an intermediate benzylisoquinoline. The resulting racemic mixture was separated by chiral column chromatography to provide pure (+)- and (−)-1.
