Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata

Kazuki Fujii; Yasumasa Hara; Midori A. Arai; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.1248/cpb.c22-00556

Regular Articles

Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata

Kazuki Fujii, Yasumasa Hara , Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

著者情報

キーワード: B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity, Mammea siamensis, Andrographis paniculata, coumarin, labdane diterpene

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2022 年 70 巻 12 号 p. 885-891

DOI https://doi.org/10.1248/cpb.c22-00556

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抄録

A new coumarin derivative (1) and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata, guided by B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity. Among the isolated compounds, 15 compounds showed BMI1 promoter inhibitory activity, and five compounds were found to be cytotoxic. 14-Deoxy-11,12-dehydroandrographolide (18) was highly cytotoxic to DU145 cells with an IC₅₀ value of 25.4 µM. Western blotting analysis of compound 18 in DU145 cells suggested that compound 18 suppresses BMI1 expression.

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