Communication to the Editor
Site-Selective α-Alkylation of 1,3-Butanediol Using a Thiophosphoric Acid Hydrogen Atom Transfer Catalyst
2022 年 70 巻 8 号 p. 540-543
詳細
2022 年 70 巻 8 号 p. 540-543
Herein, we developed secondary-alcohol-selective C–H alkylation of 1,3-butane diol by combining an acridinium photoredox catalyst and a thiophosphoric acid hydrogen atom transfer (HAT) catalyst. The use of non-coordinating solvent such as dichloromethane (DCM) improved secondary α-alkoxy C–H selectivity by lowering bond dissociation energy (BDE) through intramolecular hydrogen bonding.
