Synthetic Study of C1–C13 Intermediate in Phoslactomycins and Leustroducsins

Abstract

Phoslactomycins and leustroducsins are highly functionalized polyketides. In this paper, we report the new synthetic method for the C1–C13 fragment. This method involves a Suzuki–Miyaura coupling reaction between the C3–C7 acetylene and C8–C13 iodoolefin, followed by construction of the lactone part. The C8–C9 diol is constructed by dihydroxylation in the late stage of the synthesis.