4-Desmethyl 7-Prenyl Mollicellin Analogue Isolated from Chaetomium brasiliense

Shuntaro Morita; Sho Furumura; Yohei Morishita; Taro Ozaki; Hanako Fukano; Yoshihiko Hoshino; Aki Hirabayashi; Masato Suzuki; Yoshiteru Oshima; Teigo Asai

doi:10.1248/cpb.c25-00729

Regular Article

4-Desmethyl 7-Prenyl Mollicellin Analogue Isolated from Chaetomium brasiliense

Shuntaro Morita ^†, Sho Furumura ^†, Yohei Morishita, Taro Ozaki, Hanako Fukano, Yoshihiko Hoshino, Aki Hirabayashi, Masato Suzuki, Yoshiteru Oshima, Teigo Asai

Author information

Shuntaro Morita ^†
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980–8578, Japan
Sho Furumura ^†
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980–8578, Japan
Yohei Morishita
https://orcid.org/0000-0001-8442-8642
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980–8578, Japan
Taro Ozaki
https://orcid.org/0000-0002-4673-4478
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980–8578, Japan
Hanako Fukano
https://orcid.org/0000-0003-2143-1160
Leprosy Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo 189–0002, Japan
Yoshihiko Hoshino
https://orcid.org/0000-0002-3132-0715
Leprosy Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo 189–0002, Japan
Aki Hirabayashi
https://orcid.org/0000-0003-3115-0645
Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo 189–0002, Japan
Masato Suzuki
https://orcid.org/0000-0001-8975-2193
Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo 189–0002, Japan
Yoshiteru Oshima
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980–8578, Japan
Teigo Asai Corresponding author
https://orcid.org/0000-0002-8903-392X
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980–8578, Japan
Author contributions

†These authors contributed equally: Shuntaro Morita, Sho Furumura

Keywords: mollicellin, depsidone, polyketide, antibiotic, fungus

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Supplementary material

2026 Volume 74 Issue 2 Pages 170-174

DOI https://doi.org/10.1248/cpb.c25-00729

Details

Abstract

A new depsidone, termed mollicellin Z2 (1), and three known mollicellins D, H, and I (2–4), were isolated from cultured Chaetomium brasiliense NBRC 6548 mycelia. The structure of 1 was determined from one dimensional (1D) and 2D-NMR and high resolution electron ionization (HREI)MS spectra. It is the first 4-desmethyl mollicellin analogue found to contain a C-7 prenyl group and is likely generated via a biosynthetic pathway that is distinct from those that produce the 27 known analogues. This is the first report of mollicellin derivatives with antibacterial activity against nontuberculous mycobacteria.

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