Asymmetric Conjugate Addition of Thiophene Derivative to Nitrostyrenes Using Thiourea Organocatalysts

Abstract

The asymmetric α-regioselective conjugate addition of 2-thienylacetones to nitrostyrenes was achieved using a tertiary amine–thiourea organocatalyst, affording the α-addition products in high yields with excellent stereoselectivities. This study provides the first demonstration of an asymmetric α-regioselective conjugate addition of 2-thienylacetones to nitroalkenes.