Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei

Yuan-Hao Liu; Chih-Kai Hsu; Liu-Guo Zheng; Su-Ying Chien; Yu-Jen Wu; Jih-Jung Chen; Mingzi M. Zhang; Zhi-Hong Wen; Yuan-Bin Cheng; Lun Kelvin Tsou; Mei-Chin Lu; Jyh-Horng Sheu; Shih-Hsiung Lin; Ping-Jyun Sung

doi:10.1248/cpb.c26-00274

Regular Article

Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei

Yuan-Hao Liu ^†, Chih-Kai Hsu ^†, Liu-Guo Zheng, Su-Ying Chien, Yu-Jen Wu, Jih-Jung Chen, Mingzi M. Zhang, Zhi-Hong Wen, Yuan-Bin Cheng, Lun Kelvin Tsou, Mei-Chin Lu, Jyh-Horng Sheu, Shih-Hsiung Lin , Ping-Jyun Sung

Author information

Yuan-Hao Liu ^†
Department of Surgery, Division of Cardiovascular Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan
Department of Surgery, National Defense Medical University, Division of Cardiovascular Surgery, Tri-Service General Hospital, Taipei 114201, Taiwan
Chih-Kai Hsu ^†
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
Liu-Guo Zheng
National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
Su-Ying Chien
X-Ray Laboratory, the Institute of Chemistry, Academia Sinica, Taipei 115201, Taiwan
Yu-Jen Wu
Yu Jun Biotechnology Co., Ltd., Donggang, Pingtung 928003, Taiwan
Jih-Jung Chen
Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan
Mingzi M. Zhang
Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli 350401, Taiwan
Zhi-Hong Wen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
Yuan-Bin Cheng
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
Lun Kelvin Tsou
Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 350401, Taiwan
Mei-Chin Lu
National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan
Jyh-Horng Sheu
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
Shih-Hsiung Lin Corresponding author
Antai Medical Care Corporation Antai Tian-Sheng Memorial Hospital, Pingtung 928004, Taiwan
Ping-Jyun Sung Corresponding author
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan
Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City 242062, Taiwan
Department of Biochemistry and Molecular Medicine, National Dong Hwa University, Hualien 974301, Taiwan
Department of Traditional Medicine, School of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
Institute of Marine Ecology and Conservation, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
Author contributions

†These authors contributed equally: Yuan-Hao Liu, Chih-Kai Hsu

Keywords: Briareum stechei, briarane, briastecholide, briaexcavatolide, cytotoxicity

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Supplementary material

2026 Volume 74 Issue 8 Pages 635-643

DOI https://doi.org/10.1248/cpb.c26-00274

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Abstract

An encrusting, algae-associated octocoral, Briareum stechei, afforded three 8,17-epoxybriarane diterpenoids, including the known compound briaexcavatolide B (1) and two previously undescribed analogues, briastecholides Q (2) and R (3). The absolute configuration of 1 was established for the first time by single-crystal X-ray diffraction analysis. The planar structures and relative configurations of 2 and 3 were determined through extensive spectroscopic analyses. In bioactivity evaluation, compound 2 exhibited cytotoxic effects toward the human acute lymphoblastic leukemia cell lines Molt-4 and CCRF-CEM.

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