Doxorubicin-loaded Zein in situ gel for interstitial chemotherapy

Xiaoying Cao; Jianning Geng; Suwen Su; Linan Zhang; Qian Xu; Li Zhang; Yinghua Xie; Shaomei Wu; Yongjun Sun; Zibin Gao

doi:10.1248/cpb.c12-00270

This article has now been updated. Please use the final version.

Doxorubicin-loaded Zein in situ gel for interstitial chemotherapy

Xiaoying Cao, Jianning Geng, Suwen Su, Linan Zhang, Qian Xu, Li Zhang, Yinghua Xie, Shaomei Wu, Yongjun Sun, Zibin Gao

Author information

Keywords: interstitial chemotherapy, in situ gel, laser scanning confocal microscopy, microdialysis, local pharmacokinetic mathematical model

JOURNAL FREE ACCESS Advance online publication

Article ID: c12-00270

DOI https://doi.org/10.1248/cpb.c12-00270

The final version of this article is now available: Vol. 60 (2012), No. 10

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Abstract

A novel drug delivery system of doxorubicin (DOX)-loaded Zein in situ gel for interstitial chemotherapy was investigated in this study. The possible mechanisms of drug release were described according to morphological analysis by optical microscopy and Scanning electronic microscope (SEM). In vitro and in vivo anti-tumor activity studies showed that DOX-loaded Zein in situ gel was superior to DOX solution. Local pharmacokinetics in tumor tissue was studied by quantitative analysis with confocal laser scanning microscopy (CLSM) combined with microdialysis technology. A pharmacokinetics mathematical model of DOX-loaded Zein in situ gel in tumors was then built.

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