College of Chemistry and Materials Engineering, Quzhou University
Yi Jin
College of Chemistry and Materials Engineering, Quzhou University
Yan-wen Lv
College of Chemistry and Materials Engineering, Quzhou University Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology
A novel series of quinolone derivatives (6a-6n) were designed and synthesized, and their biological activities were evaluated as potential antitumor Top I inhibitors. Among these compounds, 6j exhibited the most potent antitumor activities against multiple cancer cell lines. Docking simulation was performed to insert compound 6j into the crystal structure of DNA-Top I to determine the probable binding model.
