Synthesis and in vitro evaluation of 1, 3, 4-thiadiazol-2-yl urea derivatives as novel AChE inhibitors

抄録

1, 3, 4-thiadiazole and urea group were hybridized to form new molecular skeleton and 11 compounds were synthesized and evaluated as AChE inhibitors. Most of them showed comparable effects in inhibition of AChE, especially compound 6b which exhibited activity with IC₅₀ value 1.17 μM, as strong as galanthamine. This information offered by our research would be valuable for further investigation of SAR and useful in future research of AChE inhibitors.