Synthesis of Antifungal Evaluation of 2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones

Chung-Kyu Ryu; Sun Young Oh; Soo Jung Choi; Da Young Kang

doi:10.1248/cpb.c14-00527

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Synthesis of Antifungal Evaluation of 2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones

Chung-Kyu Ryu , Sun Young Oh, Soo Jung Choi, Da Young Kang

著者情報

キーワード: Keywords : antimicrobial, antifungal, fungi, 2H-[1,2,3]triazolo[4,5-g]isoquinoline-4,9-dione

ジャーナルフリー早期公開

論文ID: c14-00527

DOI https://doi.org/10.1248/cpb.c14-00527

この記事には本公開記事があります。

The final version of this article is now available: Vol. 62 (2014), No. 11 pp. 1119-1124

詳細

抄録

2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones and 2H-[1,2,3]triazolo[4,5-g]quinoline-4,9-diones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Many of those synthesized showed potent antifungal activity. Compounds 3a, 3b, 3g, and 3h completely inhibited the growth of all fungal species tested at the MIC level of 0.8~12.5 μg/mL. The results suggest that 2H-[1,2,3]triazolo[4,5-g]isoquinoline-4,9-diones could be antifungal agents.

責任著者(Corresponding author)

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