Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates

Keisuke Tomohara; Koji Kasamatsu; Tomoyuki Yoshimura; Takumi Furuta; Takeo Kawabata

doi:10.1248/cpb.c16-00272

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates

Keisuke Tomohara, Koji Kasamatsu, Tomoyuki Yoshimura, Takumi Furuta, Takeo Kawabata

著者情報

キーワード: axially chiral enolate, asymmetric synthesis, chiral C-O axis, dihydrobenzofuran, conjugate addition, restricted bond rotation

ジャーナルフリー早期公開

論文ID: c16-00272

DOI https://doi.org/10.1248/cpb.c16-00272

この記事には本公開記事があります。

The final version of this article is now available: Vol. 64 (2016), No. 7 pp. 899-906

詳細

抄録

Enantioselective intramolecular conjugate addition reactions of short-lived C-O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96% ee.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）