Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers

Nguyen Hai Dang; Nguyen Dinh Chung; Ha Manh Tuan; Nguyen Tuan Hiep; Nguyen Tien Dat

doi:10.1248/cpb.c16-00743

This article has now been updated. Please use the final version.

Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers

Nguyen Hai Dang , Nguyen Dinh Chung, Ha Manh Tuan, Nguyen Tuan Hiep, Nguyen Tien Dat

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Keywords: Ophiopogon japonicas, homoisoflavanone, homoisoflavane, homoisopogon, cytotoxicity

JOURNAL FREE ACCESS Advance online publication

Article ID: c16-00743

DOI https://doi.org/10.1248/cpb.c16-00743

The final version of this article is now available: Vol. 65 (2017), No. 2 pp. 204-207

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Abstract

A phytochemical fractionationof a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B–D (2–4). Their chemical structures were elucidated by mass, NMR, and CD spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against LU-1, KB, and SK-Mel-2 cancer cells with IC₅₀ values ranging from 0.51 to 0.66 μM.

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