Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta

Ninh Thi Ngoc; Pham Thi Mai Huong; Nguyen Van Thanh; Nguyen Thi Phuong Chi; Nguyen Hai Dang; Nguyen Xuan Cuong; Nguyen Hoai Nam; Do Cong Thung; Phan Van Kiem; Chau Van Minh

doi:10.1248/cpb.c16-00881

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Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta

Ninh Thi Ngoc, Pham Thi Mai Huong, Nguyen Van Thanh, Nguyen Thi Phuong Chi, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam , Do Cong Thung, Phan Van Kiem, Chau Van Minh

著者情報

Ninh Thi Ngoc
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Graduate University of Science and Technology, VAST
Pham Thi Mai Huong
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Van Thanh
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Thi Phuong Chi
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Hai Dang
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Xuan Cuong
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Hoai Nam 責任著者
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Do Cong Thung
Institute of Marine Environment and Resources, VAST
Phan Van Kiem
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Chau Van Minh
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

キーワード: Sinularia conferta, Alcyoniidae, soft coral, steroid, cytotoxic activity

ジャーナルフリー早期公開

論文ID: c16-00881

DOI https://doi.org/10.1248/cpb.c16-00881

この記事には本公開記事があります。

The final version of this article is now available: Vol. 65 (2017), No. 3 pp. 300-305

詳細

抄録

Twelve steroids, including five new compounds 1−5, were isolated and structurally elucidated from a methanol extract of the Vietnamese soft coral Sinularia conferta. Their cytotoxic effects against three human cancer cell lines, lung carcinoma (A-549), cervical adenocarcinoma (Hela), and pancreatic epithelioid carcinoma (PANC-1), were evaluated using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assays. Among isolated compounds, 10 exhibited potent cytotoxic effects on all three tested cell lines with IC₅₀ values of 3.64 ± 0.18, 19.34 ± 0.42, and 1.78 ± 0.69 μM, respectively.

責任著者(Corresponding author)

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