論文ID: c17-00129
Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2), were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados. Their cytotoxic effect against a panel of eight human cancer cell lines was evaluated using sulforhodamine B (SRB) method. Significant cytotoxicity against hepatoma cancer (HepG2, IC50 = 21.13±0.70 µM) and colon adenocarcinoma (SW480, IC50 = 28.65±1.53 µM) cell lines were observed for 1 and against acute leukemia (HL-60, IC50 = 20.53±2.26 µM) and SW480 (IC50 = 26.61±1.59 µM) for ergost-5-en-3β,7β-diol (8). In addition, 3β,7β-dihydroxyergosta-5,24(28)-diene (13) showed significant cytotoxic activity on all tested cell lines with IC50 values ranging from 13.45±1.81 to 29.01±3.21 μM.
