Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Cobalt-catalyzed Hydroamination of Alkenes with 5-Substituted Tetrazoles: Facile access to 2,5-Disubstituted Tetrazoles and Asymmetric Intermolecular Hydroaminations
Kenzo Yahata Yuki KanekoShuji Akai
著者情報
ジャーナル フリー 早期公開

論文ID: c20-00068

この記事には本公開記事があります。
詳細
抄録

Herein, we describe a novel synthetic method for 2,5-disubstituted tetrazoles from 5-substituted tetrazoles using cobalt-catalyzed intermolecular hydroamination reaction of nonactivated olefins. Owing to its mild conditions, the method enabled the use of substrates having acid-labile functional groups, such as silyloxy and methoxymethyloxy groups. By using optically active cobalt complexes, asymmetric intermolecular hydroamination of nonactivated olefins, a longstanding challenge in synthetic organic chemistry, was developed to produce optically active disubstituted tetrazoles.

著者関連情報
© 2020 The Pharmaceutical Society of Japan
feedback
Top