Atractylodes macrocephala Koidz’s rhizomes contain anti-inflammatory sesquiterpenes

Cao Thanh Hai; Nguyen Thi Luyen; Do Hoang Giang; Bui Quang Minh; Nguyen Quang Trung; Pham The Chinh; Dang Viet Hau; Nguyen Tien Dat

doi:10.1248/cpb.c22-00779

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Atractylodes macrocephala Koidz’s rhizomes contain anti-inflammatory sesquiterpenes

Cao Thanh Hai, Nguyen Thi Luyen, Do Hoang Giang, Bui Quang Minh, Nguyen Quang Trung, Pham The Chinh, Dang Viet Hau, Nguyen Tien Dat

著者情報

キーワード: Atractylodes macrocephala, eudesmane, secoatractylolactone, anti-inflammation, atractylenolide III

ジャーナルフリー早期公開

論文ID: c22-00779

DOI https://doi.org/10.1248/cpb.c22-00779

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2023), No. 6 pp. 451-453

詳細

抄録

Two new compounds, named eudesm-4(15),7-diene-3α,9β,11-triol (1) and eudesm-4(15),7-diene-1β,3α,9β,11-tetraol (2) together with three known sesquiterpene lactones (1S,5R,7R,10R)-secoatractylolactone (3), (1S,5R,7R,10R)-secoatractylolactone-11-O-β-D-glucopyranoside (4) atractylenolide III (5) were isolated from the rhizomes of Atractylodes macrocephala. Their structures were elucidated by using 1D and 2D-NMR spectra and HRESIMS data. Compound 5 exhibited the most active anti-inflammatory activity with IC₅₀ values of 27.5 μM in inhibiting of nitric oxide production. Compounds 1, 2, and 3 showed moderate effects while compound 4 was inactive.

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