抄録
The metabolic fate of PAS and Ac-PAS in rabbits was studied comparatively. About 74% of the 1g./kg. dose of PAS administered orally is excreted in the urine. Of this, 23∼60% are unchanged, 17∼42% as acetylated compounds, and 2∼3% as a glucuronide. About 1% of a 1.27g./kg. dose of Ac-PAS administered orally is deacetylated and 42∼68% is excreted in the unchanged form. PAS glucuronide was identified by means of paper chromatography. There were three unknown metabolites containing a free amino group in the urine and no increase in ethereal sulfate nor considerable decarboxylation of either PAS or Ac-PAS were observed.
