抄録
The excretion rates of EHB and 3-keto-EHB in the urine of intact or partially hepatectomized animals receiving EHB or 3-keto-EHB were determined by use of paper chromatography in conjunction with ultraviolet spectrophotometry. Unchanged EHB was undetectable in the urine of intact animals. Approximately 44% of EHB administered was converted to 3-keto-EHB and excreted independently of the dosage. The excretion of 3-keto-EHB began in a period of the first 3 hrs. after an administration of EHB and completed within 24 hrs. (100 or 200 mg./kg.) or 48 hrs. (400 mg./kg.). About 32% of 3-keto-EHB administered was rapidly excreted but the fate of the remainder was undetectable. Partial hepatectomy prolonged the period of excretion of 3-keto-EHB and decreased the quantity of that. Unchanged EHB was detected in partially hepatectomized rats.
