医薬品の生体内変化に関する研究(第7報)メチルヘキサビタールの生体内変化 その3 メチルへキサビタール代謝物について

抄録

The three metabolites of methylhexabital (5-cyclohexenyl-3, 5-dimethylbarbituric acid) were isolated from the urine of rabbits receiving MHB and their structures were established as cyclohexenylmethyl-N-methylacetylurea, and 5-(3'-oxocyclohex-1'-enyl)- and 5-(3'-hydroxycyclohex -1'-enyl)-3, 5-dimethylbarbituric acid. Their yield was about 0.5%, 1%, and 5% of the dose administered, respectively.