Pharmaceutical Bulletin
Online ISSN : 1881-1345
Print ISSN : 0369-9471
ISSN-L : 0369-9471
Studies on Compounds related to Pyrazine. I. Synthesis of 2-Substituted Oxazolo [b] quinoxaline.
志甫 伝逸田上 昇一郎
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1957 年 5 巻 1 号 p. 45-47

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2-Substituted oxazolo [b] quinoxaline with a new skeleton was synthesized by heating 2-amino-3-quinoxalinol with excess of acyl chlorides at 180∼210°, by boiling with three volumes of acyl chlorides in nitrobenzene, or by heating 2-acylamino-3-quinoxalinol with phosphoryl chloride. When the 2-substituted radical of oxazolo [b] quinoxaline is aliphatic, 2-substituted oxazolo [b] quinoxaline was not obtained but the compounds formed when the substituents were aromatic radicals. This problem is now under investigation.
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© The Pharmaceutical Society of Japan
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