Abstract
Fifteen compounds of 10-(ω-dialkylaminoalkyl)-alkylphenothiazine series, nine compounds of 10-(2-pyridiniumacetyl)-alkylphenothiazine series, three compounds of 10-[2-(1-piperidyl)-acetyl]-alkylphenothiazine series, and three compounds of 10-(2-trimethyl-ammoniumacetyl) alkylphenothiazine iodide series, which were substituted with alkyl group in 1-, 2-, or 3-position of the phenothiazine ring, were synthesized and their antiviral activity on adenovirus was tested by the tissue culture method. Among these compounds, 10-(3-diethylaminopropyl)-3-methyl-and 10-(3-diethylaminopropyl)-3-ethylphenothiazine, and all compounds of 10-(2-pyridiniumacetyl)-alkylphenothiazine chloride series were found to possess direct inactivating effect on the adenovirus. On cytopathogenic effect induced by adenovirus, 10-(3-diethylaminopropyl)-3-methyl and 10-(3-diethylaminopropyl)-3-ethyl derivatives also inhibited in 5×TCD50 of virus.
