Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Potential Anti-cancer Agents. V. 3, 6-Disubstituted 4-Nitropyridazine 1-Oxides and their Derivatives
板井 孝信佐子 茂
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ジャーナル フリー

1962 年 10 巻 10 号 p. 933-935

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抄録
When 3-methoxy- and 3-hydroxy-6-chloropyridazine 1-oxides (Ia, b) were nitrated with nitric acid and concentrated sulfuric acid, mono-nitro compounds (IIa.b) were produced.(IIa) was shown as 4-nitro compound, (IIa) was converted to 3-methoxy-4, 6-dichloropyridazine 1-oxide (IV) with acetyl chloride. The reaction of (IIa) and (IV) with sodium methoxide occurred at their 4-positions respeetively.
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© The Pharmaceutical Society of Japan
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