Abstract
The condensation of guanidine nitrate with acetaldehyde-ammonia furnished 2-imino-4, 6-dimethylhexahydro-s-triazine nitrate. 2-Imino- 5-methylhexahydro-s-triazine nitrate was also prepared by the same way.
The alkyl derivatives of tetrahydro-s-triazine-2 (1H)-thione and tetrahydro-s-triazin-2 (1H)-one were synthesized by the condensation of either thiourea or urea with amine and aldehyde.
These compounds were screened as to their inhibitory effect on poliomyelitis virus by tissue culture method. Only 2-Imino-4, 6-dimethylhexahydro-s-triazine nitrate, among the compounds screened, showed an effect, and it exerted fairly an inhibitory effect on the type-1 and -2 strains of poliomyelitis virus, but it has not so significant effect on the type-3 strain. Moreover, this compound was found to inhibit a multiplication of the Edmonstan strain of measles virus, although its effect was not so significant.
