Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).
1962 年 10 巻 2 号 p. 91-95
詳細
1962 年 10 巻 2 号 p. 91-95
The ester-type glucuronide of p-hydroxybenzoic acid was isolated as two derivatives from the urine of rabbits receiving p-hydroxybenzoic acid and their structures were established as methyl (p-methoxybenzoyl 2, 3, 4-tri-O-acetyl-β-D-glucopyranosid) uronate and methyl (p-acetoxybenzoyl 2, 3, 4-tri-O-acetyl-β-D-glucopyranosid) uronate. When feeding p-hydroxybenzoic acid to rabbits, similarly as in using the methyl ester, the unchanged acid, p-hydroxyhippuric acid, the ether-type glucuronide, the estertype glucuronide, and p-carboxyphenyl sulfate were excreted as five metabolites in the urine.
