Studies on Food Additives. VIII. Metabolism of α-Hydroxy-2, 6-di-tert-butyl-p-cresol. Isolation of Metabolites.

抄録

3, 5-Di-tert-butyl-4-hydroxy-benzoic acid, 4, 4'-ethylenebis (2, 6-di-tert-butylphenol), and unchanged α-hydroxy-2, 6-di-tert-butyl-p-cresol were isolated and characterized from the urine of a rabbit dosed with α-hydroxy-2, 6-di-tert-butyl-p-cresol. The isolated 3, 5-di-tert-butyl-4-hydroxy-benzaldehyde was identified as its 2, 4-dinitrophenylhydrazone. A glucuronide was isolated as its triacetyl-methyl ester. Antioxidative effect of 2, 6-di-tert-butyl-p-cresol and its derivatives on vitamin A was examined.