Synthesis and Antimicrobial Activity of 1-Acyl-2-sulfanilyhydrazine and 1-Acyl-2-(4-amino-1-naphthylsulfonyl) hydrazine.

抄録

1-Acyl-2-sulfanilylhydrazine, 1-acyl-2-(4-amino-1-naphthylsulfonyl) hydrazine and their acyl derivatives were synthesized and their antimicrobial activity was examined. Among the derivatives of 1-acyl-2-sulfanilylhydrazine series, several compounds showed a weak in vitro activity on tubercle bacilli, but none of the compounds exerted any antibacterial or antiviral activity. On the contrary, there were found one compound having activity against tubercule bacilli comparable to that of INAH and dihydrostreptomycin, and two compounds having in vivo effect on Japanese B encephalitis virus equal to that of N-(4-amino-1-naphthylsulfonyl) dodecanamide, among the derivatives of 1-acyl-2-(4-amino-1-naphthylsulfonyl) hydrazine, but none of the compounds showed any activity against Escherichia coli communi or Staphylococcus aureus.