Abstract
dl-Demethoxydeoxy-hexahydrocolchicine (I) was derived to dl-colchiceine (V) by changing the C-ring in (I) to a tropilidene ring (II) and to the tropone compound (III), its amination to form dl-colchiceinamide (IV), and its saponification. Thus, the total synthesis of racemic colchiceine (V) from 1-O-methylpyrogallol was successfully concluded. Partial synthesis of colchiceinamide (IV) from the levorotaory (I) was also carried out.
