Abstract
It was shown that stereospecific hydrogenation of 2-methyl-1, 2, 3, 4, 8, 8a-hexahydro-6 (7H)-isoquinolinone (X) over palladium-charcoal proceeded in trans in neutral solution and in cis in acidic solution. Moreover, reduction of trans-and cis-2-methyloctahydro-6 (5H)-isoquinolinone gave two epimeric 6-isoquinolinol bases, respectively, that is, four isomeric alcohols in all.
