Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Acetylenic Compounds. XXI. Ring Closure. (3). New Synthetic Method for Thiazoles.
由良 靖雄
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ジャーナル フリー

1962 年 10 巻 5 号 p. 372-376

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It was found that the compounds containing primary halogen group adjacent to a triple bond, when reacted with thiourea, afforded heterocyclic compounds. In this case no six-membered ring compound was fromed but a five-membered ring compound, thiazole derivative, was obtained. This is a new synthetic method for preparing thiazoles. The reaction mechanism of this ring closure was discussed.
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© The Pharmaceutical Society of Japan
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