Studies on Pyridazine Derivatives. IV. N-Oxidation of 3-Aminopyridazine and Its Ring Substitutes.

Abstract

It was found that N-oxidation of 3-acetamidopyridazine gave a mixture of 1-oxide and 2-oxide and the 2-oxide had a tautomeric N-acetoxy from, while N-oxidation of 3-acetamido-6-methoxypyridazine, 3-amino-6-methoxypyridazine and 3-amino-6-chloropyridazine afforded exclusively 2-oxide.