Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Application of Chromatography. XLV. On the Mechanism of Biosynthesis of 6-Methyl-7-hydroxyribolumazine.
Mitsuko AsaiKomei MizunoSatoru Kuwada
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1963 Volume 11 Issue 1 Pages 23-28

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Abstract
It was evidenced that action of the enzyme of Eremothecium ashbyii on 6, 7-dimethylribolumazine produced formaldehyde and formic acid, besides riboflavin, and 6-methyl-7-hydroxyriboumazine. The experimental data obtained support the mechanism suggested by Plaut for the formation of riboflavin. As for the formation of 6-methyl-7-hydroxyribolumazine, however, it has been proved that the compound was produced by oxidative rupture of the 7-methyl group of 6, 7-dimethylribolumazine, and this result gave an experimental ground to the assumption of Korte, et al.
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© The Pharmaceutical Society of Japan
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