Potential Anti-cancer Agents. VIII. Nitration of Pyridazine 1-Oxide. (1).
1963 年 11 巻 1 号 p. 83-90
詳細
1963 年 11 巻 1 号 p. 83-90
Pyridazine 1-oxide (I) was nitrated to 4-nitropyridazine 1-oxide (II) with a mixed acid under a vigorous condition. The structure of II was confirmed as follows. i) Hydrogenation of II itself and methoxypyridazine 1-oxide (VI), derived from II, gave the known 4-aminopyridazine and 4-methoxypyridazine, respectively. ii) Pyridazinol 1-oxide obtained by hydrolysis of VI formed N-methoxypyridazinone with methyl p-toluenesulfonate and sodium methoxide. iii) VI was identical with the compound obtained by hydrogenation of 4-methoxy-3, 6-dicholoropyridazine 1-oxide, whose structure was established by its correlation to the known 3, 4, 6-trimethoxypyridazine 1-oxide. In addition, some reactions related to II were described.
