Synthesis of Polyhydroxy-steroids. II. Syntheses of Isomeric 5α-Pregnane-3, 5, 6, 16, 20-pentols and Related Compounds.

Abstract

In view of the finding that 5α-pregnane-3β, 5, 6β, 16β, 20α-pentol (POL) shows an interesting sodium excreting activity similar to that of SEF in the animal test, a number of polyoxygenated pregnanes possessing the hydroxyl or the carbonyl groups at the positions of C-3, C-5, C-6, C-16, and C-20 were synthesized. Syntheses of 3β, 5, 6β, 16α-tetrahydroxy-5α-pregnan-20-one-a hybrid compound of POL and SEF-was also described.