Studies on Decomposition and Stabilization of Drugs in Solution. XIV. Stabilization of Methantheline Bromide and Choline Derivatives in Aqueous Solution by Surface-active Agents.

Abstract

1) The decomposition of methantheline bromide was repressed by the addition of alkyl sulfate (anionic surfactant). The longer the alkyl chain length of alkyl sulfate, the greater the effect was. 2) The addition of surfactant enhanced the stability of cholinesters, and the effect increased with the acyl chain length.