Studies on Tertiary Amine Oxides. XV. Reaction of Quinoline 1-Oxide with Acetyl Cyanide.

Abstract

While quinoline 1-oxide itself is not capable to react with acetyl cyanide, an exothermic reaction occurred in the presence of acetic anhydride, and quinaldonitrile and 2-quinolinepyruvonitrile were obtained. The former was a sole product from the reaction in dioxane or chloroform, whereas the latter was the main product without solvent.