Metabolism of Drugs. XXXV. Metabolic Fate of Meprobamate. (3). A New Metabolic Pathway of Carbamate Group : The Formation of Meprobamate N-Glucuronide in Animal Body.

Abstract

The structure of meprobamate-N-glucuronide, one of the principal metabolites of meprobamate, was established as meprobamate-N-mono-β-D-glucopyranosiduronic acid by direct condensation of meprobamate and glucuronic acid. It was also proved that this glucuronide was not formed spontaneously during the course of extraction but only by enzyme system in animal body.