The Synthesis of 3-Spirooxindole Derivatives. III. Stereospecific Syntheses of rac-N-Methylrhynchophyllane for Stereochemistry of Rhynchophylline and Isorhynchophylline.

Abstract

N-Methylrhynchophyllane which is derived from the alkaloids, rhynchophylline and isorhynchophylline, was stereospecifically synthesized and was isolated as two pairs of stereoisomers, thereby establishing the trans-arrangement at C_6' and C_7' of these alkaloids.