Abstract
In order to find antiviral compound, alkyl group was introduced into the neurotropic structure of ephedrine and activity of the resulting alkyl derivatives were examined against the Nakayama strain of Japanese B encephalitis virus, Type-1 Mahoney strain of polio virus and Type-1 strain of adeno virus. Among these derivatives, [2-(3, 4-dimethylphenyl)-2-hydroxyisopropyl] trimethylammonium iodide and 1-(2-methoxy-5-methylphenyl)-2-aminopropanol showed in vitro effect, and only the former exerted in vivo activity on the Nakayama strain.
