抄録
In order to find antiviral compound, alkyl group was introduced into the neurotropic structure of ephedrine and activity of the resulting alkyl derivatives were examined against the Nakayama strain of Japanese B encephalitis virus, Type-1 Mahoney strain of polio virus and Type-1 strain of adeno virus. Among these derivatives, [2-(3, 4-dimethylphenyl)-2-hydroxyisopropyl] trimethylammonium iodide and 1-(2-methoxy-5-methylphenyl)-2-aminopropanol showed in vitro effect, and only the former exerted in vivo activity on the Nakayama strain.
