Studies on Streptomyces Antibiotic, Cycloheximide. XV. Hydroxycarbonylation of Optically Active 2, 4-Dimethylcyclohexanones with Glutarimide-β-acetaldehyde. : Synthesis of Isocycloheximide and its Isomers.

Abstract

Hydroxycarbonylation of optically active 2, 4-dimethylcyclohexanone with glutarimide-β-acetaldehyde was carried out using N-methylanilinomagnesium bromide as a condensation agent, isocycloheximide, α-epi-isocycloheximide and other isomers of cycloheximide being obtained.