Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Coenzyme Analogs. XVI. Synthesis of 9-D-Erythrityl-adenine and its Phosphates.
Morio IkeharaEiko Ohtsuka
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1963 Volume 11 Issue 9 Pages 1095-1101

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Abstract
9-D-Erythrityladenine was synthesized from 4, 6-dichloro-5-aminopyrimidine and 2, 4-O-ethylidene-erythritylamine, followed by the cyclization with acetic anhydride and ethyl orthoformate. The phosphorylation of erythrityladenine was achieved by the general method using P-diphenyl P'-morpholino pyrophosphorochloridate described in earlier report. 2', 3'-Di-O-acetylerythrityladenine 4'-triphosphate was obtained as decahydrate in a pure state.
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© The Pharmaceutical Society of Japan
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