Studies on Protein-Sulfhydryl Reagents. I. Synthesis of Benzimidazole Derivatives of Maleimide ; Fluorescent Labeling of Maleimide.

Yuichi Kanaoka; Takamitsu Sekine; Minoru Machida; Yaeko Soma; Kazutaka Tanizawa; Yoshio Ban

doi:10.1248/cpb.12.127

Yuichi Kanaoka, Takamitsu Sekine, Minoru Machida, Yaeko Soma, Kazutaka Tanizawa, Yoshio Ban

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JOURNAL FREE ACCESS

1964 Volume 12 Issue 2 Pages 127-134

DOI https://doi.org/10.1248/cpb.12.127

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Abstract

N- [(4(or 7)-Methoxy-2-benzimidazolyl) methyl] maleimide (IIIa) was synthesized as"fluorescence-labeled"protein-sulfhydryl reagent. Polyphosphoric acid was proposed to be a general reagent for imide cyclization reaction. Fluorescent characteristics of some benzimidazole derivatives were described.

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