Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Thioamides. II. Application of Thioamides in Bischler-Napieralski Reaction.
山田 俊一アブドールーモハッセン エム.イー.オマール
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1964 年 12 巻 2 号 p. 249-252

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Thioamides have been cyclized in good yield to the corresponding 1-substituted 3, 4-dihydroisoquinoline under the normal Bischler-Napieralski reaction conditions which are generally used to cyclize acid amides. Phosphorus pentasulfide has been effectively used as a condensing agent in the Bischler-Napieralski reaction to get 1-substituted-3, 4-dihydroquinoline from both thioamides as well as normal acid amides.
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© The Pharmaceutical Society of Japan
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