Rearrangement of Sulfonamide Derivatives. V. Syntheses of Methyl α-Phenyl-2- and 4-piperidineacetate.

抄録

Heating of N-phenylacetyl-2- and 4-pyridinesulfonamide 1-oxides in 10% sodium hydroxide at 90∼95°caused rearrangement reaction to form α-phenyl-2- and 4-pyridineacetic acid 1-oxides respectively. Their respective esterification and catalytic reduction with platinum-catalyst gave the hydrochloride of methyl 2- and 4-piperidineacetate and ethyl 2-piperidineacetate.