Author's Organization：Central Research Laboratory, Daiichi Seiyaku Co., Ltd. Central Research Laboratory, Daiichi Seiyaku Co., Ltd. Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
In the 2-amino-6-substituted-9-β-D-ribofuranosylpurines series, 6-hydrazino (VI), 6-methylhydrazino (VIII), 6-hydroxylamino (VII), 6-methylamino (X), and 6-dimethylamino (XI) derivatives were synthesized by condensation of 6-alkylthioguanosines with respective amines. VI and VII were reduced with Raney nickel to 2, 6-diamino derivative (IX). Similarly, VIII was also reduced with Raney nickel to X.
